Thymosin Beta-4 (TB4)
Thymosin beta-4 (TB4) is a peptide molecule expressed during embryonic development and in adults, capable of increasing myocardial cell migration, endothelial cell proliferation, and capillary formation. Systemic injection of TB4 improves post-ischemic cardiac function in adult mammals, inhibits myocardial cell death, initiates coronary re-growth and activates endogenous vessel and myocardial progenitor cells of the adult heart. TB4 is able to reactivate the embryonic program of the adult mammalian heart and the regenerative capacity is independent of injury. Researchers propose that postnatal administration of developmentally relevant candidate molecules, such as TB4, may accelerate organ regeneration and reverse aging processes.