SLU-PP-332 (Sloop)

SLU-PP-332, also known as sloop in the bodybuilding world, is a synthetic compound that activates estrogen-related receptors (ERRs), with the strongest effect on ERRα (EC₅₀ = 98 nM) and moderate activation of ERRβ and ERRγ. These receptors play a crucial role in regulating cellular energy metabolism.

Key Benefits & Mechanisms:

- Mitochondrial Function: In vitro studies show that SLU-PP-332 enhances mitochondrial respiration and increases the expression of ERR target genes in skeletal muscle cells.

- Exercise Endurance: In mice, administration of SLU-PP-332 extended running time by 70% and distance by 45%, making it a powerful exercise mimetic that improves stamina.

- Metabolic Health: Research in models of metabolic syndrome indicates that SLU-PP-332 increases energy expenditure, promotes fatty acid oxidation, reduces fat mass, and improves insulin sensitivity.

Potential Applications:

- SLU-PP-332 may be beneficial for athletes, individuals with insulin resistance, and those adjusting to high altitudes. Additionally, activation of ERRα is linked to longevity benefits, making this compound of interest in anti-aging and metabolic health research.