Sirolimus (Rapamycin)

[ sir-oh-lih-muhs (rah-puh-my-sin) ]

Sirolimus, also known as Rapamycin, is a powerful longevity drug known to extend lifespan by up to 20% in most species. It is widely used in the longevity field as a senolytic, with low-dose administration once a week to remove old, damaged cells and promote the growth of healthy ones. High doses of Rapamycin have been used as a chemotherapy agent and immunosuppressant for transplant patients, but at low doses it acts as a rejuvenating agent. For more information on its effects and benefits, see the review article linked here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/pdf/aging-11-102355.pdf

Origin

Rapamycin was discovered by a team of scientists led by Dr. Suren Sehgal, a Canadian researcher, while he was working at Ayerst Laboratories (now Wyeth Pharmaceuticals) in 1972. The team was investigating microbial compounds and isolated rapamycin from a bacterium called Streptomyces hygroscopicus found in a soil sample collected from Easter Island (Rapa Nui).