Polyamines, which decrease with age, have been associated with various age-related diseases. Spermine, the first polyamine discovered centuries ago (found in semen), along with spermidine and putrescine, have been extensively studied for their anti-aging benefits. Polyamines induce autophagy by inhibiting a key nutrient sensing pathway and mimicking a calorie deficit in the body.
Polyamines, present in all types of cells, whether prokaryotic or eukaryotic, are vital for cell viability and function. Their impacts on overall health are diverse and include essential roles in cell growth, DNA stabilization, RNA transcription, and protein response. Research on polyamine biology and metabolism opens up possibilities for disease treatment.
Polyamines are crucial for cell growth and play a significant role in regulating metabolism. Dysregulation of polyamine metabolism is often observed in cancer and other diseases, making targeting polyamine metabolism pathways a promising approach in cancer treatment. Polyamines are found in various plant and animal products including: