Pentosan Polysulfate Sodium (PPS)
PPS is a sulfated polysaccharide derived from beechwood, known for its anti-inflammatory properties. Historically used to treat bladder pain, recent studies suggest its potential in managing joint degeneration, such as osteoarthritis, by promoting cartilage restoration, recovering bone bruises, nourishing cartilage surfaces, and preventing degradation. However, caution should be exercised with patients who have allergies to components of PPS, are on blood-thinning medication, or have a personal or family history of pigmentary macular degeneration.
PPS, also known as Zilosul, is a groundbreaking polysulfate medication used to treat pain caused by various factors, including injury, inflammation, aging, disease, infection, or genetics. It reduces inflammation by decreasing key mediators and can result in decreased pain and cartilage degradation. Possible side effects include mild blood thinning, hair loss, injection site irritation, immune reactions, nausea, rash, or gastrointestinal distress. Currently in phase 3 trials in the US, PPS has been available in other countries for years.
- BLI's Regenerative Orthopedic Services
- Repurposing PPS for New Indications
- Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues - March 2023 Research Report
- Paradigm 2021 Research Report
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- PPS in Osteoarthritis
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- Health Benefits of PPS Chart
- Potential Uses of Pentosan Table
- Sodium Pentosan Polysulfate Resulted in Cartilage Improvement in Knee OA
- Paradigm PPS 2023