The MTHFR gene codes for the MTHFR enzyme which help a process called methylation. The MTHFR enzyme participates in many functions including brain function, turning genes on/off, DNA repair, detoxing toxins, and metabolism.
The 1298 gene specifically has been shown to decrease BH4 production and therefore reduce the ability to rid ammonia. It also depletes neurotransmitters and can contribute to depression, anxiety, addictive behaviors and more.
The 677 gene is correlated to reduced distribution of folate which compromises our ability to recycle homocysteine. Consequently, elevated levels of homocysteine are common and put you at risk for developing CVD.