The mitochondrial-derived peptide MOTS-c, composed of 16 amino acids, is encoded from the 12S rRNA region of the mitochondrial genome. In times of stress, MOTS-c travels to the nucleus where it regulates numerous genes in response to metabolic imbalances. Found in various tissues and plasma, MOTS-c's levels decline with age. Its crucial cellular functions and potential hormonal role have demonstrated benefits for age-related conditions, including Diabetes, Cardiovascular disease, Osteoporosis, obesity in postmenopausal women, and Alzheimer's disease. Aging is marked by a gradual loss of metabolic balance, muscle homeostasis, and physical capability, which could potentially be reversed by MOTS-c treatment.