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The process of freeze-drying or the removal of moisture from a frozen material using a vacuum. In peptide therapy, this method is used to increase stability of the molecules without destroying their physical structure. The lyophilized peptides can be reconstituted with bacteriostatic water to return them to their active state. Lyophilized peptides are shelf stable for months to years and do not require refrigeration.

Lyophilized peptides have several advantages. The removal of water helps to enhance their stability and prolong their shelf life, as many peptides are susceptible to degradation or loss of activity in aqueous solutions. Lyophilized peptides are also more convenient for storage and transportation since they are stable at room temperature and have a longer expiration date.