Low Dose Naltrexone (LDN)
LDN, or Low Dose Naltrexone, is the use of naltrexone medication at a lower dose, usually 1/10th or 4.5mg, compared to its typical dose of 50mg. It's used to treat autoimmune disease, cancer, and other conditions that affect the immune system. Research also suggests benefits for chronic pain, autoimmune disorders, and central nervous system disorders. LDN regulates the immune system by promoting regulatory T-Cells, which balance the immune system and control inflammation. It has been shown to reduce symptoms of inflammatory conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and CRPS (complex regional pain syndrome). LDN is generally safe and well-tolerated, with some temporary side effects like vivid dreams, GI upset, headache, and agitation. It's available in liquids, capsules, sublingual drops, and topical creams, and dosed at bedtime after a 2-3 week gradual increase. LDN is not recommended for patients taking opiates as it may block their effectiveness and induce withdrawal symptoms.