Cellular Senescence

[ Sell-yoo-lar sih-nes-uhns ]

Cellular senescence is a state in which cells lose their ability to divide and replicate, essentially entering a state of permanent growth arrest. It is a natural biological process that occurs as cells age or in response to various stressors such as DNA damage or oxidative stress. While cellular senescence plays a role in normal development and wound healing, an accumulation of senescent cells over time can contribute to aging and age-related diseases. Senescent cells are believed to have detrimental effects on surrounding tissues and can promote chronic inflammation and tissue dysfunction. Researchers are actively studying cellular senescence and exploring interventions to remove or mitigate senescent cells as a potential therapeutic approach for age-related conditions.