Alpha-2-Macroglobulin, more commonly referred to as A2M, is a naturally-occurring molecule that acts as a master protease inhibitor. A2M is part of the body's defense mechanism and acts as a powerful inhibitor of cartilage breakdown, inflammation, as well as pain. While A2M is found naturally in the bloodstream, it is not able to enter the joint or disc spaces in large enough quantities and therefore must be concentrated from your blood, isolated, and reinjected to the injury site. A2M injections can be used to treat joint pain conditions, osteoarthritis, joint injuries, labral tears, torn meniscus, spinal injuries, spinal and sacral joint pain, radiculopathy, herniated discs, degenerative disc disease, and more. A2M has been well studied in both its efficacy and safety, and is overall well tolerated by patients. A2M works by depositing a rich supply of A2M proteins directly into the injury, and once injected cause proteases to bind and remove the destructive/painful enzymes from your joint. Regular, early, and repeat treatments can relieve pain, decrease inflammation, promote tissue growth, and prevent the progression of degenerative diseases and even post-traumatic osteoarthritis.