5α-DHT, or 5α-dihydrotestosterone, is a potent androgenic hormone derived from testosterone, which is one of the primary male sex hormones. It is produced in various tissues in the body, primarily in the prostate gland, hair follicles, and testes.

The "5α" in 5α-DHT refers to a specific chemical modification that occurs in the testosterone molecule, resulting in the formation of dihydrotestosterone (DHT). This modification makes DHT significantly more potent than testosterone in terms of its androgenic effects.

5α-DHT plays a crucial role in the development and maintenance of male sexual characteristics, including the growth of facial and body hair, deepening of the voice, and the development of the male genitalia during fetal development. It also has a role in regulating the prostate gland and can contribute to conditions like benign prostatic hyperplasia (BPH) and male pattern baldness (androgenic alopecia).

While 5α-DHT is important for male development and health, imbalances or excessive levels of DHT can lead to various health issues, such as hair loss or prostate problems. Medications like finasteride and dutasteride are sometimes prescribed to inhibit the conversion of testosterone into DHT, which can help manage these conditions.